Human Thioredoxin-related transmembrane protein 4 (TMX4) ELISA Kit

TMX4, a type I transmembrane protein, was localized to the ER and possessed a Trx-like domain that faced the ER lumen. A maleimide alkylation assay showed that a catalytic CXXC motif in the TMX4 Trx-like domain underwent changes in its redox state depending on cellular redox conditions, and, in the normal state, most of the endogenous TMX4 existed in the oxidized form. The redox potential of this domain indicated that TMX4 could work as a reductase in the environment of the ER. TMX4 had no effect on the acceleration of ER-associated degradation. Because TMX4 interacted with calnexin and ERp57 by co-immunoprecipitation assay, the role of TMX4 may be to enable protein folding in cooperation with these proteins consisting of folding complex in the ER.

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SPECIFICATIONS

Catalog Number

KTE60239

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

56255

Accession

Q9H1E5

Additional Info

Human Thioredoxin-related transmembrane protein 4 (TMX4) ELISA Kit has high sensitivity and excellent specificity for detection of Human TMX4. No significant cross-reactivity or interference between Human TMX4 and analogues was observed.