Human Thymidine kinase 2, mitochondrial (TK2) ELISA Kit

Thymidine kinase (EC 2.7.1.21) catalyzes the phosphorylation of thymidine to deoxythymidine monophosphate. Genetic variation in soluble thymidine kinase has not been identified in man. Weiss and Green (1967) found that fusion of mouse cells lacking this enzyme with normal human cells could be achieved, that progressive loss of human chromosomes from the hybrid occurred with passage of time, and that at a stage when only one human chromosome remained the cell still had the capacity to synthesize thymidine kinase. Two forms of Thymidine kinase 1, soluble have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

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SPECIFICATIONS

Catalog Number

KTE62325

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

7084

Accession

O00142

Additional Info

Human Thymidine kinase 2, mitochondrial (TK2) ELISA Kit has high sensitivity and excellent specificity for detection of Human TK2. No significant cross-reactivity or interference between Human TK2 and analogues was observed.