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Human TIP41-like protein (TIPRL) ELISA Kit

Human TIP41-like protein (TIPRL) ELISA Kit

Cat no: KTE60320

Supplier: Abbkine Scientific Co.Ltd.
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TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A), PP4 , and PP6. TIP isoform-2 did not interact with PP2A, suggesting that the C terminus of TIP is important for PP2A binding. Incubation of PP2A with TIP, but not TIP isoform-2, resulted in dose-dependent inhibition of PP2A phosphatase activity. Cells in which TIP was depleted by small interfering RNA exhibited decreased phosphorylation of a 32-kD substrate of ATM/ATR kinases. TIP is an inhibitory regulator of PP2A and that the TIP/PP2A complex has a role within the ATM/ATR signaling pathway controlling DNA replication and repair.The predicted protein contains 272 amino acids. Immunoblot analysis showed ubiquitous expression of a 33-kD TIP protein.
Catalogue number: KTE60320
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: O75663
Gene: 261726
Additional info: Human TIP41-like protein (TIPRL) ELISA Kit has high sensitivity and excellent specificity for detection of Human TIPRL. No significant cross-reactivity or interference between Human TIPRL and analogues was observed.

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