Human Toll-like receptor 4 (TLR4) ELISA Kit

TLR 4 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness.

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SPECIFICATIONS

Catalog Number

KTE60314

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

7099

Accession

O00206

Additional Info

Human Toll-like receptor 4 (TLR4) ELISA Kit has high sensitivity and excellent specificity for detection of Human TLR4. No significant cross-reactivity or interference between Human TLR4 and analogues was observed.