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Human TRAF2 and NCK-interacting protein kinase (TNIK) ELISA Kit

Cat no: KTE60200


Supplier: Abbkine Scientific Co.Ltd.
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TNIK was autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain. Immunoprecipitation analysis showed that epitope-tagged TNIK coprecipitated endogenous TRAF2 from human embryonic kidney cells. Mutation analysis revealed that the intermediate domain was sufficient for the interaction, although the GCK domain may contribute. The intermediate domain was also sufficient for interaction with NCK. Cotransfection of TNIK with JNK2 (MAPK9) enhanced JNK2 kinase activity in a dose-dependent manner, and this effect was mediated by the GCK region of TNIK, but not the kinase domain. TNIK overexpression had no effect on ERK1 (MAPK3), p38 (MAPK14), or NF-kappa-B.
Catalogue number: KTE60200
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: Q9UKE5
Gene: 23043
Additional info: Human TRAF2 and NCK-interacting protein kinase (TNIK) ELISA Kit has high sensitivity and excellent specificity for detection of Human TNIK. No significant cross-reactivity or interference between Human TNIK and analogues was observed.

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