Triggering Receptor Expresses on Myeloid Cells-1 (TREM-1) belongs to the Ig superfamily that is expressed on myeloid cells. TREM-1 amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for TREM-1.
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