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Human Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) ELISA Kit

Human Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) ELISA Kit

Cat no: KTE60234

Supplier: Abbkine Scientific Co.Ltd.
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Tumor necrosis factor, alpha-induced protein 3 is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B.
Catalogue number: KTE60234
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: P21580
Gene: 7128
Additional info: Human Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) ELISA Kit has high sensitivity and excellent specificity for detection of Human TNFAIP3. No significant cross-reactivity or interference between Human TNFAIP3 and analogues was observed.

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