Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine with a myriad of innate immune anti-tumor properties. TNF-alpha has a critical role in the bone and cartilage damage associated with rheumatoid arthritis (RA)[1]. TNF-alpha may be involved in the pathogenesis and/or progression of gestational diabetes mellitus (GDM) [2]. TNF-alpha is expressed in myocardium during compensated pressure-overload hypertrophy and contributes to postischemic myocardial dysfunction [3]. The serum levels of TNF-alpha were also significantly elevated in active WG (Wegener's granulomatosis) [4], in the late stages of HIV-associated disease [5], and in the spinal cord of arthritic patients [6].