Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) ELISA Kit

TRAILR3, a novel member of the TRAIL receptor family. Although the open reading frame potentially encoded a 299-amino acid protein, the authors suggested that translation begins at amino acid 41, yielding a protein of 259 amino acids. TRAILR3 contains a predicted signal sequence, 2 of the 4 cysteine-rich pseudorepeats characteristic of the extracellular domain of members of the TNF receptor family, an extracellular linker sequence, and a short, hydrophobic C-terminal sequence. Transient expression studies showed that TRAILR3 is a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand. In contrast to TRAILR1 and TRAILR2, TRAILR3 appears to be glycosylphosphatidylinositol-linked and lacks a cytoplasmic region, including the death domain.

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SPECIFICATIONS

Catalog Number

KTE60226

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

8794

Accession

O14798

Additional Info

Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) ELISA Kit has high sensitivity and excellent specificity for detection of Human TNFRSF10C. No significant cross-reactivity or interference between Human TNFRSF10C and analogues was observed.