Human Tumor necrosis factor soluble receptor II (TNFsR-II) ELISA Kit

TNFsR-II encodes a member of the TNF receptor superfamily of proteins. Tumor necrosis factor soluble receptor II is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.

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SPECIFICATIONS

Catalog Number

KTE60216

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

7132

Accession

P19438

Additional Info

Human Tumor necrosis factor soluble receptor II (TNFsR-II) ELISA Kit has high sensitivity and excellent specificity for detection of Human TNFRSF1A. No significant cross-reactivity or interference between Human TNFRSF1A and analogues was observed.