Human Tumor suppressor p53-binding protein 1 (TP53BP1) ELISA Kit

TP53BP1 has a predicted molecular mass of 217 kD and shows homology in its C-terminal 247 amino acids to the C terminus of the tumor suppressor protein BRCA1. TP53BP1 was present in both the cytoplasm and nucleus in some cells and only in the nucleus in others. Furthermore, there were 2 nuclear staining patterns, one homogeneous staining and the other dot staining.TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation. TP53BP1 played a partially redundant role in phosphorylation of the downstream checkpoint effector proteins BRCA1 and CHK2 but was required for the formation of BRCA1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.

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SPECIFICATIONS

Catalog Number

KTE60155

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

7158

Accession

Q12888

Additional Info

Human Tumor suppressor p53-binding protein 1 (TP53BP1) ELISA Kit has high sensitivity and excellent specificity for detection of Human TP53BP1. No significant cross-reactivity or interference between Human TP53BP1 and analogues was observed.