Human Tyrosine-protein kinase Blk (BLK) ELISA Kit

The BLK gene is a nonreceptor protein tyrosine kinase with a calculated molecular mass of about 58 kD. It has an overall amino acid identity of approximately 87% to the mouse Blk; however, in the unique domain of Src family members there is only 58% homology and an insertion of 6 amino acids in the N-terminal region. The nature of this insertion suggested a functional role in membrane attachment. Mutation screening of each exon by direct sequencing of genomic DNA from KWE patients did not reveal any pathogenic mutation. Because BLK is a member of the SRC family, which is thought to play an important role in the signaling pathways controlling cell proliferation and differentiation, the authors considered the gene to be a good positional candidate for the cancers mapping to this region.

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SPECIFICATIONS

Catalog Number

KTE62435

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

640

Accession

P51451

Additional Info

Human Tyrosine-protein kinase Blk (BLK) ELISA Kit has high sensitivity and excellent specificity for detection of Human BLK. No significant cross-reactivity or interference between Human BLK and analogues was observed.