Human Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) ELISA Kit

Cat no: KTE60107

Supplier: Abbkine Scientific Co.Ltd.

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Using a human sequence homologous to the bovine UACA sequence to screen a Jurkat cell cDNA library, they isolated the human homolog, which was found have the same sequence as KIAA1561. Human UACA encodes a deduced 1,449-amino acid protein with a predicted molecular mass of approximately 166 kD. It contains 6 ankyrin repeats, a leucine zipper motif, and coiled-coil domains. The bovine and human proteins share 86% sequence homology. Northern blot analysis demonstrated expression at various levels in all tissues analyzed, with highest expression in skeletal muscle.the prevalence of IgG anti-UACA autoantibodies in patients with panuveitis was significantly higher than that in healthy controls (19.6-28.1% vs 0%, p less than 0.05), indicating that autoimmunity directed against UACA is a common phenomenon in these diseases.

Catalogue number:	KTE60107
Reactivities:	Human
Applications:	ELISA
Size:	48T, 96T, 96T5, 96T50
Accession:	Q9BZF9
Gene:	55075
Additional info:	Human Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) ELISA Kit has high sensitivity and excellent specificity for detection of Human UACA. No significant cross-reactivity or interference between Human UACA and analogues was observed.

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Human Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) ELISA Kit

Cat no: KTE60107

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