Human Vascular Endothelial Growth Factor 121 (VEGF121) ELISA Kit

Cat no: KTE60061

Supplier: Abbkine Scientific Co.Ltd.

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VEGF165 is an angiogenic cytokine that also regulates vascular permeability.The neuropilin-1 (np1) receptor binds the 165 amino-acid form of VEGF165 and functions as an enhancer that potentiates VEGF165 signaling via the VEGFR-2 tyrosine-kinase receptor. A VEGF165 mutant (VEGF165KF) that binds to neuropilins but displays a much lower affinity toward VEGFR-1 and VEGFR-2. VEGF165KF failed to induce VEGFR-2 phosphorylation in cells lacking neuropilins. However, in the presence of np1, VEGF165KF bound weakly to VEGFR-2, induced VEGFR-2 phosphorylation, and activated ERK1/2. Interestingly, VEGF165KF did not promote formation of VEGFR-2/np1 complexes nor did high concentrations of VEGF165KF inhibit VEGF165 induced formation of such complexes, suggesting that VEGF165 does not stabilize VEGFR-2/np1 complexes by forming bridges spanning VEGFR-2 and np1.

Catalogue number:	KTE60061
Reactivities:	Human
Applications:	ELISA
Size:	48T, 96T, 96T5, 96T50
Additional info:	Human Vascular Endothelial Growth Factor 121 (VEGF121) ELISA Kit has high sensitivity and excellent specificity for detection of Human VEGF121. No significant cross-reactivity or interference between Human VEGF121 and analogues was observed.

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Human Vascular Endothelial Growth Factor 121 (VEGF121) ELISA Kit

Cat no: KTE60061

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