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Human WNT1-inducible-signaling pathway protein 1 (WISP1) ELISA Kit

Cat no: KTE60032

Human WNT1-inducible-signaling pathway protein 1 (WISP1) ELISA Kit

WISP1 encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.

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SPECIFICATIONS

Catalog Number

KTE60032

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

8840

Accession

O95388

Additional Info

Human WNT1-inducible-signaling pathway protein 1 (WISP1) ELISA Kit has high sensitivity and excellent specificity for detection of Human WISP1. No significant cross-reactivity or interference between Human WISP1 and analogues was observed.

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