Hyaluronidase, Ovine

Hyaluronidase is an enzyme that temporarily and reversibly breaks down the polysaccharide, hyaluronic acid, which is found between the cells of connective tissue. Hyaluronic acid may be thought of as the "glue" that holds cells together. hyaluronic acid is a mucopolysaccharide that exists in the human tissue matrix. It can constrain the diffusion of the extracellular fluid. Hyaluronidase makes the glucoseamine of the hyaluronic acid molecules hydrolyzed and depolymerized, thus decreases the viscosity of the body fluids and increases the flow and diffusion of the intercellular fluids. In this way the physic liquor, exudates or blood in local areas can be more easily diffused, and the drug can be more easily absorbed. Thus the local tissue tension and pains can be relieved. And it will also be easier for the edema and inflammatory exudates to be absorbed and dissolved. This product is a basic component of the articular cartilage. It can nourish, protect and maintain the functions of the joints.\n\nActivity: \n~1500IU/mg.\n\nStorage and Stability: \nLyophilized powder may be stored at -20 degrees C. Reconstitute to nominal volume by adding sterile ddH20, 0.1% HSA or BSA . Aliquot and store with dessicants at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

H7981-05A

Size

1500U

Form

Supplied as a lyophilized powder without additives. Reconstitution: Reconstitute with sterile ddH20, 0.1% HSA or BSA to (same/more than)0.1mg/ml which can then be further diluted to other aqueous solutions.

References

1. Comparison of bovine- and recombinant human-derived hyaluronidase with regard t1. Comparison of bovine- and recombinant human-derived hyaluronidase with regard to fertilization rates and embryo morphology in a sibling oocyte model: a prospective, blinded, randomized study.Fertil Steril 2006 May;85(5):1544-6 2. Hyaluronidase for cervical ripening and induction of labour. Cochrane Database Syst Rev 2006 Apr 19;(2):CD003097 3. Hypoxia-induced alterations in hyaluronan and hyaluronidase. Adv Exp Med Biol 2005;566:249-56 4. Raised intraocular pressure and orbital inflammation: a rare IgE-mediated allergic reaction to sub-Tenon's hyaluronidase. J Cataract Refract Surg 2006 Jan;32(1):177-8 5. Effect of hyaluronidase and bicarbonate on local anaesthetic pH. Anaesth Intensive Care 2005 Dec;33(6):820-1 6. Role of hyaluronidase in subcutaneous spread and growth of group A streptococcus. Infect Immun 2006 Jan;74(1):40-8