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IBMX (3-Isobutyl-1-methylxanthine)

Cat no: I0465-50


Supplier: United States Biological
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IBMX is a nonspecific inhibitor of phosphodiesterases that also possesses adenosine agonist activity. Biological Activity: IC50=2-50uM Solubility: DMSO and ethanol Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: I0465-50
Size: 1g
Form: Supplied as a white solid lyophilized powder. Reconstitute with sterile dH2O to 0.1-1mg/ml.
Purity: ~99% (TLC)
References: 1. Beavo, J.A., et al. (1970) Effects of xanthine derivatives on lipolysis and on adenosine 3',5'- monophosphate phosphodiesterase activity. Mol. Pharmacol. 6(6):597-603. 2. Coffin, V.L. and R.D. Spealman (1989) Psychomotor-stimulant effects of 3-isobutyl-1- tethylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline. Eur. J. Pharmacol. 170(1-2):35-40. 3. Saavedra, A.P., et al. (2002) Role of cAMP, PKA and Rap1A in thyroid follicular cell survival. Oncogene 21(5):778-788. 4. van Staveren, W.C., et al. (2001) The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat. Brain Res. 888(2):275-286. 5. Simonsson, E., et al. (2000) The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation. Biochem. Biophys. Res. Commun. 269(1):242-246.

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