Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110e (IC?? =60nM). Inhibits p110a and p110b only at higher concentrations (>1uM). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100uM.
Solubility:
DMSO
Molecular Weight:
~397.43
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.