ICAD, Recombinant Human (DFF 1, DFF 45, DFF alpha, DFF1, DFF35, DFF45, DFFA, DNA Fragmentation Factor alpha subunit, Inhibitor of Caspase Activated DNase)

Supplier:

United States Biological

Cat no: I0505-05T

ICAD, Recombinant Human (DFF 1, DFF 45, DFF alpha, DFF1, DFF35, DFF45, DFFA, DNA Fragmentation Factor alpha subunit, Inhibitor of Caspase Activated DNase)

DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA, also known as DNA fragmentation factor subunit alpha, is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Recombinant DFFA protein , expressed in E. coli and purified by using conventional chromatography techniques.\n\nSource:\nRecombinant corresponding to human DFFA, aa1-331, His-tagged, expressed in E. coli\n\nMolecular Weight: \n~38.7kD\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL AIDKSLTPVT LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD GGTAWISQES FDVDETDSGA GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV DAPCSDLAQE LRQSCATVQR LQHTLQQVLD QREEVRQSKQ LLQLYLQALE KEGSLLSKQE ESKAAFGEEV DAVDTGISRE TSSDVALASH ILTALREKQA PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE WELALRLQQT QSLHSLRSIS ASKASPPGDL QNPKRARQDP T\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.

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SPECIFICATIONS

Catalog Number

I0505-05T

Size

100ug

Form

Supplied as liquid in 20mM Tris-HCl buffer, pH 8.0, 10% glycerol, 1mM DTT.

Purity

~90% (SDS-PAGE) Purified by immunoaffinity chromatography.

References

1.McCarty JS., et al. (1999) Biochem Biophys Res Commun. 264(1):176-80. 2. Gu J., et al. (1999) J Biol Chem. 274(30):20759-62.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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