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iCRT-14

iCRT-14

Cat no: 014719

Supplier: United States Biological
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A potent inhibitor of b-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between b-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
Catalogue number: 014719
Size: 10mg
Alternative names: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione; iCRT 14; iCRT14;
References: Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011); Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011);

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