IDE (Insulin-degrading Enzyme, Abeta-degrading Protease, Insulin Protease, Insulinase, Insulysin)

IDE is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulin's activity, as well as participating in intercellular peptide signaling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in IDE's function are associated with Alzheimer's disease and type 2 diabetes mellitus, but mutations in IDE have not been shown to be causative for these diseases. It localizes primarily in the cytoplasm, but in some cell types it localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested. \n\nRecommended Dilutions: \nWestern Blot: 1:1000-1:10,000 \nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.\n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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