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IFN-gamma

Cat no: 030315

IFN-gamma

Interferon-g (IFN-g) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-g strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB\n\nApplications:\nWestern Bloting: 1:500-1:2000.\nELISA: Suggested dilution 1:10000.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

030315

Size

100ul

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Purified antibody in PBS, 0.03% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1. Takayanagi, H. et al. Nature 2000. 408: 600-605.\n2. Tsubota, K. et al. Invest. Ophthal. Vis. Sci. 40: 28-34, 1999.

Additional Info

Human

Alternative Names

IFG; IFI

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