logo
logo
IGF-BP1, Recombinant, Human (Insulin-like Growth Factor-Binding Protein 1, IBP-1, Placenta Protein 12 (PP12))

Cat no: 143372

IGF-BP1, Recombinant, Human (Insulin-like Growth Factor-Binding Protein 1, IBP-1, Placenta Protein 12 (PP12))

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids.Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II.IGF-BP1 is a 25.4kD cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid.Levels of IGF-BP1 in serum are lowest after food.IGF-BP1 binds to both IGF-I and IGF-II with equal affinity.Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4kD protein consisting of 235 amino acid residues (Isoform A).\n\nBiological Activity:\nThe ED50 was determined by its ability to inhibit IGF-I induced proliferation of MCF-7 is ~0.5ug/ml in the presence of 6ng/ml of human IGF-I.\n\nAA Sequence:\nMAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

143372

Size

5ug

Form

Supplied as a lyophilized powder.

Purity

(same/more than)98% by SDS-PAGE gel and HPLC analyses.

Read more on Supplier website

Latest promotions

Spend less time on DNA cleanup so you can do more science. The MSB Spin PCRapace is the fastest way to purify your DNA from PCR, restriction digestion, and...

Genovis introduces GlycINATOR&trade;&bull; Works on most IgGs&bull; Effective on high-mannose and bisected N-linked Fc-glycans &bull; Rapid &ndash; 30-minute...

Use promo code EASY3 to receive 13% off and FREE shipping!Experience a new dimension of electronic pipetting with the NEW Easypet 3 pipette controller. The...

New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon&trade; BV421 and...

As an incentive to qualify our BSA, we are offering a 20% discount when you purchase your first 100g, 500g or 1000g of any grade of Bovine Serum Albumin....

It is not every day that you are given something for nothing. We are giving away additional spectrophotometer software.Cecil Instruments have enhanced the...

We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!

For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...

10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...

Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...

Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...

Jenway&rsquo;s 73 series spectrophotometer range provides four models with a narrow spectral bandwidth of 5nm and an absorbance range of &ndash;0.3 to 2.5A,...

Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...