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IGF2BP3 (Insulin-like Growth Factor 2 mRNA-binding Protein 3, IGF2 mRNA-binding Protein 3, IMP-3, IGF-II mRNA-binding Protein 3, KH Domain-containing Protein Overexpressed in Cancer, hKOC, VICKZ Family Member 3, IMP3, KOC1, VICKZ3)

Cat no: 029512

IGF2BP3 (Insulin-like Growth Factor 2 mRNA-binding Protein 3, IGF2 mRNA-binding Protein 3, IMP-3, IGF-II mRNA-binding Protein 3, KH Domain-containing Protein Overexpressed in Cancer, hKOC, VICKZ Family Member 3, IMP3, KOC1, VICKZ3)

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. \n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation and RNA Binding Protein Immunoprecipitation assay. Other applications not tested.\n\nRecommended Dilution:\nRIP: ~5ug/RIP\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nIncludes negative control normal rabbit IgG antibody and control primers specific for the cDNA of human IGF2.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

029512

Size

10Tests

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.09% sodium azide, 30% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Nielsen,J.,etal.(1999).Molec.Cell.Biol.19: 1262-1270. 2. Martens, J.W., et al. (2003). Thromb Haemost. 89(2):393-404.

Additional Info

Recognizes human IGF2. Species Crossreactivity: mouse. Species sequence homology: Chimpanzee, rhesus monkey, canine, equine (100%).

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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