IgM, Human

Human Immunoglobulin M(Human IgM) forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, normally as a pentamer or occasionally as a hexamer. Human Immunoglobulin M(IgM) is also by far the physically largest antibody in the circulation. Due to its polymeric nature, Human Immunoglobulin M(IgM) possesses high avidity, and is particularly effective at complement activation. Human Immunoglobulin M (human IgM) is the class of immunoglobulin characterized by mu heavy chains. Human Immunoglobulin M IgM is the first immunoglobulin to appear on the surface of B cells and the first to be secreted.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I1905-10B

Size

1mg

Applications

ELISA, WB

Form

Supplied as a liquid in 0.05M Tris buffer, pH 8, 0.2M sodium chloride, 0.05% sodium azide.

Purity

(same/more than)96% (SDS-PAGE)

References

1. Human Immunoglobulin M (Human IgM) Research: A Human Monoclonal Immunoglobulin M Reduces Bacteremia and Inflammation in a Mouse Model of Systemic Pneumococcal Infection.Human Immunoglobulin M (Human IgM) REF: Clinical and Vaccine Immunology, April 2007, p. 382-390, Vol. 14, No. 4. 2. Human Immunoglobulin M (Human IgM) research: functional human Immunoglobulin IgM response to HIV-1 Env after immunization with NYVAC HIV C.Human Immunoglobulin M (Human IgM) REF: AIDS. 21(4):524-527, February 19, 2007. 3. Human Immunoglobulin M (Human IgM)Fully human Immunoglobulin IgG and Human Immunoglobulin IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers.Human Immunoglobulin M (Human IgM) REF: BMC Cancer 2004, 4:75. 4. Human Immunoglobulin M (Human IgM)research; Detecting Immunoglobulin M Antibodies against Microsporidian Encephalitozoon cuniculi Polar Tubes in Sera from Healthy and Human Immunodeficiency Virus-Infected Persons in Japan.Human Immunoglobulin M (Human IgM) REF: Clinical and Vaccine Immunology, February 2007, p. 168-172, Vol. 14, No. 2. 5. Human Immunoglobulin M (human IgM) research: Evaluation of immunoglobulin M and G capture enzyme-linked immunosorbent assay Panbio kits for diagnostic dengue infections.Human Immunoglobulin M (human IgM) ref: Journal of Clinical Virology, 22 May 2007. 6. Human Immunoglobulin M (human IgM) research:Kinetics of Immunoglobulin IgM, Imunoglobulin IgA and Immunoglobulin IgG subclasses in the serum and intestine of experimentally infected rats and mice.Human Immunoglobulin M (human IgM) research: Experimental Parasitology, February 2007. 7. Human Immunoglobulin M (human IgM) research: Detection of rubella immunoglobulin M (IgG) from dried venous blood spots using a commercial enzyme immunoassay.Human Immunoglobulin M (human IgM) ref: Diagnostic Microbiology and Infectious Disease, Volume 53, Issue 2, October 2005, Pages 107-111. 8. Human Immunoglobulin M (human IgM) research: Unmutated immunoglobulin M can protect mice from death by influenza virus infection.Human Immunoglobulin M (human IgM) ref: International Congress Series, Volume 1263, June 2004, Pages 135-140. 9. Human Immunoglobulin M (human IgM) research: Anti-b2-glycoprotein I antibodies of IgM class are linked to thrombotic disorders in young women without autoimmune disease.Human Immunoglobulin M (human IgM) research: Immunobiology, Volume 212, Issue 3, 15 May 2007, Pages 193-199. 10. Human Immunoglobulin M (human IgM) research: Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): Human Immunoglobulin M (human IgM) research: Journal of Affective Disorders, Volume 99, Issues 1-3, April 2007, Pages 237-240.11. Human Immunoglobulin M (human IgM) research:Analysis of Immunoglobulin G IgG and Immunoglobulin M IgM in patients pre-diagnosed with toxoplasmosis.Human Immunoglobulin M (human IgM) ref:International Journal of Antimicrobial Agents, Volume 29, Supplement 2, March 2007, Page S117