IkB-alpha Antibody

Cat no: 251650

Supplier: ABBIOTEC

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Description
Additional Information

IkB-alphs (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-kB transcription factor. IkB-alpha inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IkB-alpha blocks the ability of NF-kB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Mutations in the gene encoding IkB-alpha have linked to Hodgkin's lymphoma.

Catalogue number:	251650
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P25963
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IkB-alpha.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	NF-kappa B inhibitor alpha; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; Major histocompatibility comple, Xenopus/Amphibian, enhancer-binding protein MAD3; NFKBIA; IKBA; NFKBI