IKBKB Antibody

Cat no: 252687

Supplier: ABBIOTEC

0 reviews | Write a Review Pencil

Description
Additional Information

IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta, also called IKK2/IKKB) is a member of the IKK comple, Xenopus/Amphibian, which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK comple, Xenopus/Amphibian, frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta is autophosphorylated which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

Catalogue number:	252687
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 ml
Accession:	O14920
Antigen:	Purified recombinant fragment of IKBKB e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Additional info:	Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; IKBKB