IKKB, CT (Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit, I-kappa-B-kinase beta, IkBKB, IKK-beta, IKK-B, I-kappa-B Kinase 2, IKK2, Nuclear Factor NF-kappa-B Inhibitor Kinase beta, NFKBIKB, IKBKB)

IKKbeta, an IKAPPAB -type protein kinase, is a member of the multimeric IkappaB kinase complex. This complex, often consisting of IKKalpha/IKKbeta heterodimers plus regulatory IKKgamma subunits, phosphorylates IkappaB proteins, marking them for destruction and thereby allowing activation of NFkappaB and downstream nuclear genes. The constitutively expressed IKKbeta protein contains an N-terminal kinase domain, a central leucine zipper motif, and a C-terminal helix-loop-helix motif. In knockout studies, IKKbeta (-/-) mice died between embryonic day 12.5 and 14 due to extensive liver damage from apoptosis; however, they were rescued by inactivation of the tumor necrosis factor receptor 1 gene. IKKbeta has been implicated in the pathogenesis of insulin resistance in obesity and type II diabetes mellitus.\n\nApplications: \nSuitable for use in ELISA, Immunoprecipitation, Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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