IL-22Ralpha2 Peptide

IL-22Ralpha2 (interleukin-22 receptor alpha-2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2 soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22Ralpha2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is four- to ten-fold higher than that of the membrane bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22Ralpha2 prevents the binding to the IL-22 membrane bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22Ralpha2 may be important in regulating inflammatory responses. In addition, IL-22Ralpha2 can be induced by lipopolysaccharide (LPS).

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SPECIFICATIONS

Catalog Number

BS60293P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide IL-22Ralpha2. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q969J5

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS60293 IL-22Ralpha2 pAb.

Alternative Names

Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16; IL22RA2; UNQ5793/PRO19598/PRO19822