IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)

IL-23R is a 629aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12Rbeta1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

I8443-49J

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Cargill, M. et al. Am. J. Hum. Genet. 80:273-290 (2007). 2. Duerr, R. et al. Science. 314:1461-1463 (2006). 3. Parham, C. et al. J. Immun. 168:5699-5708 (2002). 4. Zhang, XY. et al. Immunogenetics. 57:934-943 (2006).

Additional Info

Recognizes human IL-23 Receptor. Species Crossreactivity: chimpanzee. Species sequence homology: bovine, canine, monkey, rat.