IL-33, Recombinant, Human (His) (Interleukin-33, IL-1F11, NF-HEV)

Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kD human IL33 is converted by CASP1 to a 18kD protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.\n\nBiological Activity:\nActivates human ST2-dependent NF-kappaB pathway.\n\nSequence:\nHuman IL-33 (aa 112-270) is fused at the C-terminus to a His-tag.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nWorking aliquots are stable for up to 3 months when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044929

Size

10ug

Form

Supplied as a liquid from a 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl.

Purity

>90% (SDS-PAGE)

References

Product Reference: \n?IL-33 can promote survival, adhesion and cytokine production in human mast cells: M. Iikura, et. al; Lab. Invest. 87, 971 (2007) \n?Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils: M. Suzukawa, et al.; Lab. Invest. 88, 1245 (2008) \n?An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor: M. Suzukawa, et al.; J. Immunol. 181, 5981 (2008)\n?

Additional Info

Binds to human ST2.

Alternative Names

Interleukin-33, IL-1F11, NF-HEV