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IL-33, Recombinant, Human (Interleukin-33, IL-1F11, NF-HEV)

IL-33, Recombinant, Human (Interleukin-33, IL-1F11, NF-HEV)

Cat no: 044930

Supplier: United States Biological
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Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kD human IL33 is converted by CASP1 to a 18kD protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. Biological Activity: Activates human ST2-dependent NF-kappaB pathway. Sequence: Human IL-33 (aa 112-270) is fused at the C-terminus to a FLAG(R)-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 044930
Size: 10ug
Form: Supplied as a 0.2um-filtered solution in PBS, pH 7.2.
Purity: >90% (SDS-PAGE)
Alternative names: Interleukin-33, IL-1F11, NF-HEV
References: Product Reference: ?Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils: M. Suzukawa, et al.; J. Immunol. 186, 5254 (2011) ?
Additional info: Binds to human ST2.

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