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IL-33, Recombinant, Human (NF-HEV)

Cat no: 143402

IL-33, Recombinant, Human (NF-HEV)

Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family.It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases.IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant human IL-33 is a 17.9kD protein containing 159 amino acid residues.\n\nBiological Activity:\nThe ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ~0.05ng/ml, corresponding to a specific activity of ~2x10e7 units/mg.\n\nAA Sequence:\nSITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET\n\nCrossreactivity:\nMouse\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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SPECIFICATIONS

Catalog Number

143402

Size

2ug

Form

Supplied as a lyophilized powder.

Purity

(same/more than)98% by SDS-PAGE gel and HPLC analyses.

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