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IL-33, Recombinant, Mouse, His-Tag (Interleukin-33, His6IL-33) (Carrier free)

Cat no: 137449

IL-33, Recombinant, Mouse, His-Tag (Interleukin-33, His6IL-33) (Carrier free)

IL-33 is a novel member of the IL-1 family of proteins that was discovered in a computational search to identify unknown family members (1). IL-33 is expressed by fibroblasts and endothelial cells, and is upregulated in response to inflammatory stimuli (1). IL-33 plays a key role in Th2 type inflammatory responses, including atopic allergic responses and asthma (1,2). The IL-33 receptor consists of the ST2 and IL-1 accessory protein (IL-1-Acp) (1,3). ST2 is expressed on mast cells, basophils and Th2 cells (1). In addition to its putative role as a Th2 cytokine, IL-33 also contains a nuclear localization domain and may function as a nuclear factor (4,5). The nuclear function of IL-33 remains unclear. IL-33 is released by cellular necrosis, similar to other

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SPECIFICATIONS

Catalog Number

137449

Size

10ug

Form

Supplied as a lyophilized powder in PBS, pH 7.2, 1mM EDTA, 3mM DTT. Reconstitute in sterile PBS.

Purity

~98% (SDS-PAGE)

References

1. Liew, F.Y. et al. (2010) Nat Rev Immunol 10, 103-10. 2. Chackerian, A.A. et al. (2007) J Immunol 179, 2551-5. 3. Borish, L. and Steinke, J.W. (2011) Curr Allergy Asthma Rep 11, 7-11. 4. Moussion, C. et al. (2008) PLoS One 3, e3331. 5. Cayrol, C. and Girard, J.P. (2009) Proc Natl Acad Sci U S A 106, 9021-6.\n6. L

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