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IL-36 beta, Recombinant, Mouse (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)

IL-36 beta, Recombinant, Mouse (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)

Cat no: 044936

Supplier: United States Biological
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IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Biological Activity: Induces secretion of IL-6 in BMDCs at a concentration of 10 - 100ng/ml. Sequence: IL-36beta (mouse) (aa 31-183) is untagged. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 6 months after receipt when stored at -20 degrees C.
Catalogue number: 044936
Size: 10ug
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2, with 0.5% trehalose.
Purity: >95% (SDS-PAGE)
Alternative names: Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8

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