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IL-36b (IL-1F8), Recombinant, Human (IL-1F8, IL-1H2, IL-1 eta)

Cat no: 143406

IL-36b (IL-1F8), Recombinant, Human (IL-1F8, IL-1H2, IL-1 eta)

The IL-1 family iscomprised of 11 structurally related ligands, including recently re-named IL-36alpha(IL-1F6), beta (IL-1F8) and gamma (IL-1F9). IL-36beta is highly expressed in psoriatic plaques, and at lower levels invarious other tissues. IL-36beta signalsthrough the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certaindendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligandsinduces dendritic cell maturation and activation. IL-36beta also functions as anagonist of NF-kappaB, and stimulates the production of pro-inflammatoryproteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36beta is a 17.3kD protein containing 154 amino acidresidues.\n\nBiological Activity:\nMeasured by its ability to induce IL-8 production by human PBMCs.\n\nAA Sequence:\nMREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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SPECIFICATIONS

Catalog Number

143406

Size

2ug

Form

Supplied as a lyophilized powder.

Purity

(same/more than)98% by SDS-PAGE gel and HPLC analyses.

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