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IL-36beta, Recombinant, Human (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)

Cat no: 044939

IL-36beta, Recombinant, Human (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.\n\nSequence:\nIL-36beta (human) (aa 5-157) (isoform 2) is untagged.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 6 months after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044939

Size

10ug

Form

Supplied as a lyophilized powder from a 0.2um-filtered solution in PBS, pH 7.2, 0.5% Trehalose.

Purity

>95% (SDS-PAGE)

Alternative Names

Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8

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