IL-36RA, Recombinant, Human (FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1, delta)

The IL-1 family is comprised of 11 structurally related ligands,including the recently re-named IL-36RA (IL-1F5), IL-36alpha (IL-1F6), IL-36beta(IL-1F8), and IL-36gamma (IL-1F9). The interaction of IL-36 ligands with theIL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendriticcell maturation and activation. IL-36RA can antagonize the NF-kappaB signalinginduced by either IL-36alpha, -beta or -gamma by binding to the IL-1Rrp2 receptor in amanner that prevents the initiation of functional signaling. Recombinant human IL-36RAis an E. coli derived 17kD proteincontaining 154 amino acid residues.\n\nBiological Activity:\nMeasured by its ability to inhibit IL-36gamma; induced IL-6 production by human PBMCs.\n\nAA Sequence:\nVLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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