IL-3R(beta) (F587) pAb

Cat no: BS1185

Supplier: Bioworld Technology, Inc.

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Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific (alpha) subunit (IL-3R(alpha)) and a signal transducing (beta) subunit (IL-3R(beta)) common to the IL-3/IL-5/GM-CSF receptors. The (alpha) subunits are low-affinity ligand-binding proteins while the (beta) subunits do not themselves bind ligand, but are required for high affinity binding by the (alpha) subunits. The mouse IL-3 receptor has two distinct (beta) subunits, one that functions only in IL-3-mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine (beta) subunits are 91% homologous at the amino acid level but only 56% homologous to the human (beta) subunit.

Catalogue number:	BS1185
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P32927
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 550-600 of Human IL-3R(beta).
Species:	IL-3R (F587) pAb detects endogenous levels of IL-3R protein.
Molecular weight:	~ 97, 130 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Cytokine receptor common subunit beta; CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD131; CSF2RB; IL3RB; IL5RB; IL3R(beta)
Additional info:	For research use only, not for use in diagnostic procedure.

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IL-3R(beta) (F587) pAb

Cat no: BS1185

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