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IL-5 (S92) pAb

IL-5 (S92) pAb

Cat no: BS3471

Supplier: Bioworld Technology, Inc.
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Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cellreplacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an (alpha) chain that binds IL-5 with low affinity and a (beta) chain that does not bind IL-5, but together with the IL-5 (alpha) chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the (alpha) and (beta) chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor (alpha) subunit, IL-5R(alpha), is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
Catalogue number: BS3471
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P05113
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 61-110 of Human IL-5.
Species: IL-5 (S92) pAb detects endogenous levels of IL-5 protein.
Molecular weight: ~ 15, 45 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF; IL5
Additional info: For research use only, not for use in diagnostic procedure.

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