Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kD-28kD phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.
Biological Activity:
Promotes growth of hybridoma/plasma cells at concentration <0.1ng /ml.
Sequence:
The extracellular domain of mouse IL-6 (aa 25-211) is fused at the C-terminus to the Fc portion of human IgG2.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Stable for at least 1 year after receipt when stored at -20 degrees C. Working aliquots are stable for up to 3 months when stored at -20 degrees C.
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