IL-6R Antibody

Cat no: 252201

Supplier: ABBIOTEC

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Description
Additional Information

Interleukin-6R binds to IL6 with low affinity, but does not transduce a signal. A soluble IL-6R is produced by both naive and memory CD4 T cells upon TCR activation. The production of IL6-R by activated CD4 T cells is mediated by shedding of the membrane-bound IL-6R, and this process correlates with the e, Xenopus/Amphibian,pression of the metalloproteinase ADAM17 in these cells. In contrast to CD4 T cells, CD8 T cells do not e, Xenopus/Amphibian,press ADAM17 and their production of IL-6R is negligible. Thus, during an immune response CD4 T cells are an important source of IL-6R. Production of IL-6R by autoreactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes.

Catalogue number:	252201
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P08887
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within human IL-6R.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA ; IL-6R 1; Membrane glycoprotein 80; gp80; CD126