IL12A (Interleukin-12 Subunit alpha, IL-12A, Cytotoxic Lymphocyte Maturation Factor 35kD Subunit, CLMF p35, IL-12 Subunit p35, NK Cell Stimulatory Factor Chain 1, NKSF1) (Carboxyfluorescein)

Interleukin 12 (IL-12) and interleukin 35 (IL-35) are heterodimeric cytokines composed of alpha and beta chains. IL-12 is composed of p35 and p40 subunits, while IL-35 is comprised of p35 paired with EBI-3. In mice, IL-35 is produced by FoxP3+ regulatory T cells and may function as an inhibitory cytokine to suppress T cell proliferation. Human FoxP3+ Tregs do not constitutively express IL-35, but expression may be induced by activated dendritic cells.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommened Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

I8434-29E

Size

100Tests

Applications

FC

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in sodium chloride, 0.5% BSA, 0.1% sodium azide. Labeled with Carboxyfluorescein.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1

References

1.Collison, L.W. and D.A.A. Vignali (2008) Immunol. Rev. 226:248. 2.Collison, L.W. et al. (2007) Nature 450:566. 3.Bardel, E. et al. (2008) J. Immunol. 181: 6898. 4.Seyerl, M. et al. (2010) Eur. J. Immunol. 40: 321.

Additional Info

Recognizes human IL-12 p35.