Il12b, ID (Il12b, Interleukin-12 subunit beta, Cytotoxic lymphocyte maturation factor 40kD subunit, IL-12 subunit p40) (PE)

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC (By similarity). Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036972-PE

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Kagami, S., et al. J. Immunol. 185(9):5453-5462(2010)\nWozniak, T.M., et al. Infect. Immun. 78(10):4187-4194(2010)\nLindsay, R.W., et al. J. Immunol. 185(3):1513-1521(2010)\nMarshall, H.D., et al. J. Immunol. 185(3):1419-1428(2010)\nPark, Y., et al. J. Immunol. 185(3):1476-1484(2010)

Additional Info

Mouse

Alternative Names

Il12b, Interleukin-12 subunit beta, Cytotoxic lymphocyte maturation factor 40kD subunit, IL-12 subunit p40