IL18 pAb

Cat no: BS6823

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1(alpha), IL-1(beta) and IL-1(gamma)/IL-18 and a specific receptor antagonist, IL-1R(alpha). IL-1(alpha) and IL-1(beta) play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1(gamma)) has been shown to augment the secretion of IFN-(gamma) from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1(alpha) and IL-1(beta) respectively over the 12 (beta)-strands of the (beta)-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1(beta) pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-(gamma)-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).

Catalogue number:	BS6823
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q14116
Dilutions:	WB: 1:500~1:2000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human IL18.
Species:	IL18 pAb detects endogenous levels of IL18 protein.
Molecular weight:	~ 23 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	IL18; IGIF; IL-18; IL-1g; IL1F4; MGC12320;
Additional info:	For research use only, not for use in diagnostic procedure.

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IL18 pAb

Cat no: BS6823

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