IL23R pAb

Cat no: BS6809

Supplier: Bioworld Technology, Inc.

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Additional Information

The p19 protein shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. p19 shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Also similar to IL-12, human IL-23 stimulates IFN-(gamma) production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. The receptors for each appear to share one subunit, but also have at least one distinct subunit. Activated dendritic cells secrete detectable this heterodimeric complex and IL-23 binds to IL-12R beta 1 and IL-23R. At least six spliced isoforms of IL-23R (IL-23R1 to 6) can be generated through alternative splicing. The IL-23R2 and/or IL-23R4 variants are predominantly detected in certain human lung carcinomas and may contribute to their pathogenesis.

Catalogue number:	BS6809
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q5VWK5
Dilutions:	WB: 1:500~1:2000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human IL23R.
Species:	IL23R pAb detects endogenous levels of IL23R protein.
Molecular weight:	~ 72 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	IL 23R; IL-23 receptor; IL-23R; IL23R; IL23R; Interleukin 23 receptor; Interleukin-23 receptor;
Additional info:	For research use only, not for use in diagnostic procedure.

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IL23R pAb

Cat no: BS6809

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