IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin's disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant mouse IL-9 is a 14.3kD protein of 127aa including 10 cysteine residues which are fully conserved between the human murine proteins.
Source:
Recombinant protein corresponding to mouse IL-9, expressed in E.coli.
Biological Activity:
Determined by the dose-dependent proliferation of human MO7e cells. The ED50 was found to be <0.5ng/ml.
Specific Activity:
>2x10e6units/mg
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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