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Il9, Recombinant, Mouse (Interleukin-9, IL-9, Cytokine P40, T-cell Growth Factor P40)

Cat no: 149701


Supplier: United States Biological
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IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin's disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant mouse IL-9 is a 14.3kD protein of 127aa including 10 cysteine residues which are fully conserved between the human murine proteins. Source: Recombinant protein corresponding to mouse IL-9, expressed in E.coli. Biological Activity: Determined by the dose-dependent proliferation of human MO7e cells. The ED50 was found to be <0.5ng/ml. Specific Activity: >2x10e6units/mg Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 149701
Size: 2ug
Form: Supplied as a lyophilized powder.
Purity: ~98% (SDS-PAGE and HPLC)

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