Ilimaquinone (3-2-hydroxy-5-methoxybenzoquinone, IQ)

Cytoplasmic microtubule inhibitor.\n Cell permeable, antimicrobial, anti-inflammatory, antimitotic and cytotoxic compound.\n Induces a complete and reversible breakdown/disruption of Golgi membranes into smaller vesicular structures.\n Blocks the association of the ADP-ribosylation factor and beta-COP to the Golgi membrane.\n Blocks protein transport to the plasma membrane and inhibits gap junctional communication.\n HIV-1 inhibitor.\n Blocks the cytotoxicity of ricin and diphtheria toxin.\n S-Adenosylhomocysteinase hydrolase inhibitor and cellular methylations inhibitor.\n DNA polymerase beta lyase activity inhibitor.\n Anti-cancer compound..\n\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044951

Size

100ug

Purity

>98% (HPLC)

References

Product Reference: \n?Ilimaquinone, a sesquiterpenoid quinone from a marine sponge: R.T. Luibrand, et al.; Tetrahedron 35, 609 (1979)\n?Microtubule independent vesiculation of Golgi membranes and the reassembly of vesicles into Golgi stacks: B. Veit, et al.; J. Cell. Biol. 122, 1197 (1993)\n?Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone: P.A. Takizawa, et al.; Cell 73, 1079 (1993)\n?The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses: S. Loya & A. Hizi; J. Biol. Chem. 268, 9323 (1993)\n?Ilimaquinone inhibits the cytotoxicities of ricin, diphtheria toxin, and other protein toxins in Vero cells: M.P. Nambiar & H.C. Wu; Exp. Cell Res. 219, 671 (1995)\n?Golgi-disturbing agents: A. Dinter & E.G. Berger; Histochem. Cell Biol. 109, 571 (1998)\n?Interactions of (-)-ilimaquinone with methylation enzymes: implications for vesicular-mediated secretion: H.S. Radeke, et al.; Chem. Biol. 6, 639 (1999)\n?Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta: S. Cao, et al.; J. Nat. Prod. 67, 1716 (2004)\n?Ilimaquinone inhibits gap junctional communication in a connexin isotype-specific manner: V. Cruciani & S.O. Mikalsen; Exp. Cell Res. 304, 136 (2005)\n?Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway: P.H. Lu, et al.; Eur. J. Pharmacol. 556, 45 (2007)\n?Comparison of the biological properties of several marine sponge-derived sesquiterpenoid quinones: C.A. Motti, et al.; Molecules 12, 1376 (2007)\n?A new structural class of S-adenosylhomocysteine hydrolase inhibitors: B.G. Kim, et al.; Bioorg. Med. Chem. 17, 6707 (2009) \n?

Alternative Names

3--2-hydroxy-5-methoxybenzoquinone, IQ