Immunoglobulin-Like Transcript 5, Recombinant, Human (ILT5, CD85a, CD85 antigen-like family member A, Leukocyte immunoglobulin-like receptor subfamily B member 3, Monocyte inhibitory receptor HL9, LILRB3, LIR3)

Immunoglobulin-like transcript 5 (ILT5), also known as leukocyte immunoglobulin-like receptor subfamily B (LILRB3), leukocyte immunoglobulin-like receptor 3 (LI R3) and CD85a, is an Ig-like recept or family member that is involved in immune regulation. ILT5 belongs to subfamily B whose members have cytoplasmic tails that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that inhibit signaling events via phosphatase SHP-1. The counterpart to subfamily B is subfamily A, whose members qualify as activating receptors that lack ITIMs, but signal through association with FcRg . ILTs share structural homology and chromosomal localization with the KIR family of receptors (1, 2). Mature ILT5 is a highly polymorphic 85-95kD glycoprotein that consists of a 420aa extracellular domain with four Ig-like domains, a 21aa transmembrane segment, and a 167aa cytoplasmic domain with three ITIMs (3, 4). Alternate splicing generates an isoform with a 17aa insertion in the juxtamembrane ECD. In mouse and rat , the LILRB3 gene encodes the PIR

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SPECIFICATIONS

Catalog Number

I7502-81

Size

50ug

Form

Supplied as a lyophilized powder from PBS, pH 7.4. Reconstitute with sterile PBS to 0.25mg/ml

Purity

(same/more than)95% by SDS-PAGE under reducing conditions and visualized with silver stain. Endotoxin:(same/less than)1EU/ug (LAL)

References

1. Brown, D. et al . (2004) Ti ssue Ant i gens 64:215. 2. Borges, L. and D. Cosman (2000) Cytokine Growth Factor Rev. 11:209. 3. Swi ssProt Accessi on # O75022. 4. Nakayama, M. et al . (2007) J. Immunol. 178:4250. 5. Tedl a, N. et al . (2003) Proc. Natl. Acad. Sci. 100:1174. 6. Sl oane, D.E. et al . (2004) Blood 104:2832. 7. Tedl a, N. et al . (2008) J. Leukoc. Biol. 83:334. 8. Mori, Y. et al . (2008) J. Immunol. 181:4742. 9. Huynh, O.A. et al . (2007) Rheumatology 46:742.