Insulin

Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B-cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B-cell origin such as insulinoma. \n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nRecommended Pair:\nSuitable for use as the capture or solid phase antibody.\nMatched to I7656-07 as the detection or conjugate (label) antibody.\n\nAffinity Constant:\n7.5 x 10e9 M-1\n\nHybridoma: \nHybridization of X63-Ag8

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SPECIFICATIONS

Catalog Number

I7656-06

Size

1mg

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Bov, Prc

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. No glycerol added.

P Type

Mab

Purity

Purified by Protein A affinity chromatography (> 90%, SDS-PAGE).

Isotype

IgG1,k

Additional Info

Recognizes human Insulin. Does not crossreact wtih free C-peptide. Species Crossreactivity: Human proinsulin, bovine insulin (30%) and porcine insulin.